| Item Name | Rarity | Stack Type | DLC | Category | Rainglish |
|---|---|---|---|---|---|
| Rusted Key | Common | - | - | Utility | Key |
| Safer Spaces | Void | Exponential | SOV | Utility | Spaces |
| Sale Star | Uncommon | Linear | SOTS | Utility | - |
| Sawmerang | Equipment | - | - | Damage | - |
| Seed of Life | Equipment | - | SOTS | Utility | - |
| Seed of Life (Consumed) | Equipment | - | SOTS | Healing | - |
| Sentient Meat Hook | Legendary | Linear, Hyperbolic | - | Damage | Hooks |
| Sentry Key | Boss | Linear | - | Utility | - |
| Shaped Glass | Lunar | Exponential | - | Damage | |
| Shared Design | Aspect | - | - | Utility | - |